Health Research

New Research and Findings on Risks & Benefits of HRT

Major news magazines, TV documentaries, radio talk show hosts and other media have paid a great deal of attention to the findings from two studies on hormone replacement therapy. A long-term study of more than 16,000 women between the ages of 50 and 79 revealed that HRT did pose some major health risks.

Hormone Replacement TherapyWhen you look at the numbers, the risks seem small. Let’s look at the math. Suppose you live in a town in which 10,000 women are taking an estrogen-progestin combination. Of those 10,000 women, chances are that eventually 30 of them will develop breast cancer, as that rate (0.3%) is the figure for women in general. What recent HRT research shows, however, is that it’s more likely that 37 women in your town will get breast cancer because of the HRT. That’s an extra 7 women. Now just an additional 7 women out of a population of 10,000 women doesn’t seem like many—that is, unless you’re one of those women!

The research also revealed that you’d expect about 18 in a normal population of 10,000 women to develop blood clots. Among women using HRT, though, that number increases to 36. The number doubles. In statistical terms, that’s a 100% increase in the likelihood of getting blood clots. Those health risks were too high to allow the study to continue.

Risks and Benefits

The Women’s Health Initiative (WHI), a group studying HRT effects among 16,000 women, found both benefits and risks to hormone replacement. Here is a summary of their research findings:

Heart Attacks, Strokes and Blood Clots

The study found that HRT increased the risk of having a heart attack or a stroke at a rate of 7 and 8 women per 10,000 respectively. The risk of blood clots increased by 18 per 10,000.

Breast Cancer

Many studies in the past gave the medical community reason to suspect that HRT might pose an extra risk for breast cancer. The study found that, like strokes, the risk increased by 8 women per 10,000.

Colorectal Cancer and Hip Fractures

While we’ve heard much about increased risks, as doctors have long suspected, some conditions actually benefit from HRT.

Many physicians prescribe HRT to prevent bone loss from osteoporosis. Brittle bones lead to fractures and a decrease in an aging woman’s quality of life. The incidence of hip fractures among women taking HRT decreased by 5 per 10,000 women.

Additionally, the incidence of colorectal cancer (cancer involving both the colon and rectum) decreased by 6 women per 10,000.

Endometrial Cancer

The use of HRT did not appear to pose any additional risk of endometrial cancer, nor did it provide any significant health benefit.

Overall Findings

When all the results were combined, the health risks of HRT so outweighed the benefits that the researchers were forced to recommend that women stop taking estrogen/progestin combinations.

According  to the WHI, per 10,000 women on HRT, risk of:

  • Breast Cancer increased by 8
  • Colorectal Cancer decreased by 6
  • Heart Attacks increased by 7
  • HIP Fractures decreased by 5
  • Blood clots increased by 18
  • Stroke increased by 8

More Evidence

Within just days of the WHI announcement, a study by the National Cancer Institute was published in the Journal of the American Medical Association (July 2002). It revealed that women taking estrogen alone (without progestin) were at high risk for ovarian cancer.

While physicians had established that women should plan to take estrogen for at least ten years to derive the benefits of preserved bone mass and relief from the ravages of osteoporosis, the National Cancer Institute’s study found that taking estrogen for ten years increased a woman’s risk of ovarian cancer by sixty percent. And women who took estrogen for 20 years would triple their risk of ovarian cancer.

The National Cancer Institute studied 44,000 women for more than 20 years. Their findings have implications for the almost 8 million women in the U.S. who take estrogen every day.

New research indicates that in addition to the health problems discussed above, women taking combination HRT (estrogen/progestin) are more likely to suffer from urinary incontinence than women taking a placebo.

The paper was presented at the April 2003 meeting of the American College of Obstetricians and Gynecologists. The study, a continuation of the Heart and Estrogen/Progestin Replacement Study (HERS), followed 1228 women with heart disease over the course of four years. The researchers found that women in the test group were, after one year on HRT, two to three times as likely to experience incontinence on a weekly basis, increasing to three to five times as likely after four years of treatment.

An increase in both urge incontinence and stress incontinence was observed. Urge incontinence is urinary leakage due to an overactive bladder, whereas stress incontinence is leakage that results from increased intra-abdominal pressure following coughing, laughing, sneezing, etc. The researchers believe the increase in incontinence may be due to the progestin component of HRT.

Be the First to comment. Read More